1. Home
  2. Research Models

Research Models

Research Models & Services

In the rapidly-evolving world of biomedical science, Fetero’s comprehensive portfolio of research models and services allows us to help our clients research, discover, and develop new therapies.

  • Research Animal Models

High-quality inbred, outbred, disease, germ-free, and immunodeficient models

  • Genetically Engineered Models & Services

Contract breeding, model creation, and embryology services

  • Research Animal Diagnostics

Diagnostic services, including environmental and microbiome testing, serology reagents, and more

  • Surgery & Preconditioning Services

Multiple species, animal identification, dosing, custom diets, and aging services

  • Genetic Testing Services

Genotyping and other genetic quality testing/assays

Modeling & Pharmacometrics

Pharmacometrics can help to better predict pharmacokinetics (PK), drug response (PD) and drug-drug interactions (DDIs). The ability to predict these aspects of your molecule in development can help you to develop a streamlined program to enable moving quickly from discovery to development.

In addition, it can also help you build better and more efficient study designs to save time and money.  We can help you in the exploration of how pharmacometrics can lead you to the next stage of your drug development program as well as implement the tools necessary to bring you the results that you need.

  1. 1
    Compartmental PK Modeling

    A compartmental PK model is generally more complex than a noncompartmental PK model and allows for prediction of modeling profiles between compartments when experimental parameters are altered. Compartmental PK is appropriate for large and small molecules.

  2. 2
    PK / PD Modeling

    PK / PD modeling creates one set of mathemtical expressions for PK & PD disciplines in order to better understand how a molecule’s dose intensity varies over time. As such, PK / PD modeling allows you to better assess ADME properties, establish safety margins and assess dosage change requirements. PK / PD modeling is often used for compartmental PK studies as well as population PK studies.

  3. 3
    PBPK Modeling

    PBPK modeling in being accepted more commonly by regulatory agencies as a way to inform clinical study designs and is also used as a way to compare therapeutic indications from multiple drug candidates. PBPK modeling does require a set of in vitro and in vivo data to verify the models.

  4. 4
    QSP / SP Modeling

    Quantiative and/or Systems Pharmacology (QSP/SP) modeling, a subdiscipline of pharmacokinetics, is an approach that integrates preclinical mechanistic evidence and physiological system models to investigate and predict drug response.

Drug Metabolism & Pharmacokinetics

Better predict pharmacokinetic (PK) and drug-drug interactions (DDIs) with DMPK/ADME studies and computational modeling on your compound, prior to clinical trials, to move quickly from discovery to development.

  1. 1
    In Vitro Metabolism

    Induction | Inhibition | Reaction Phenotyping

    Metabolic Stability

    Transporter Interactions & DDIs

    Protein Binding (PBB; plasma, etc.)

    Additionally, we can monitor for compliance with the study plan, protocol and IRB review, and control of investigational products, as well as report safety data, inform sites about performance and contractual issues, and serve as a point of contact between site, sponsor, CRO and IRBs.

  2. 2
    In Vivo Metabolism

    In Vivo Metabolism

    Fast PK | PK/TK Analysis & Reporting

    Radiolabeled ADME | hAME

    Bioequivalcence | Biosimilars

    WBA

  3. 3
    MetID

    Metabolite Identification (MetID)

    Human AME

    In Vitro / In Vivo Cross Species

    Metabolic Stability

    Radiolabeled ADME

  4. 4
    Pharmacometrics

    Compartmental PK

    PK / PD

    PBPK

    QSP / SP

Discovery & Disease Models

In vivo pharmacology, the study of the biological effects of a compound in a living organism, gives you insight into how well your compound might be able to treat your targeted disease area.

With hundreds of lead optimization pharmacology models and customized efficacy models for diseases, including oncology, immuno-oncology, cardiovascular, dermal, respiratory, immunology, fibrosis and renal, we can help you understand your drug’s profile quickly and comprehensively.

Designing, Validating & Analyzing Hundreds of Efficacy Models

Access hundreds of validated lead optimization or custom efficacy models to help you determine the right profile for your disease indication.

  1. 1
    In Vivo Pharmacology Efficacy Models

    Anxiety
    Bone
    Cardiovascular
    CNS
    Dermal
    Gastrointestinal
    Infectious disease
    Immunogenicity
    Metabolic
    Oncology / Tumor models
    Pain
    Pulmonary arterial hypertension
    Renal
    Respiratory disease

  2. 2
    In Vitro Models

    Anxiety
    Bone
    Cardiovascular
    CNS
    Dermal
    Gastrointestinal
    Infectious disease

  3. 3
    Nonclinical Imaging

    Our nonclinical imaging has generated significant utility, and we are working on cutting-edge applications of pharmaco-imaging across many therapeutic areas.

    Bioluminescence
    Computed Tomography
    Analysis
    Positron Emission